The best gaming mouse with side buttons can put abilities, macros, media controls, and essential commands within easy reach. The right layout depends on your games, hand size, grip, and tolerance for extra weight or software setup.
We compared ten popular wired and wireless options across button count, sensor resolution, ergonomics, customization, connectivity, and overall versatility so you can choose a mouse that fits the way you play.
Best 10 Gaming Mouse with Side Buttons Picks for 2026
Classic Wired Value
- Up to 7200 adjustable DPI
- Programmable buttons and macro editing
- Ergonomic shape with RGB lighting
Best For: Budget-minded right-handed gamers wanting customizable wired controls
Long-Lasting Wireless Pick
Razer Basilisk V3 X HyperSpeed
- HyperSpeed wireless and Bluetooth
- Up to 285 hours of HyperSpeed battery life
- Nine customizable controls with 18,000 DPI
Best For: Right-handed gamers seeking wireless flexibility and long battery life
MMO Command Center
- 12 programmable side buttons
- Five profiles with RGB identification
- Adjustable weights and up to 16,400 DPI
Best For: MMO players needing extensive thumb controls and macros
Precision Wired Favorite
- 11 programmable buttons
- 25,600 DPI HERO sensor
- Five adjustable weights and LIGHTSYNC RGB
Best For: Right-handed PC gamers wanting precision and customizable wired control
Best MMO Value
Redragon M901K 19-Button Gaming Mouse
- 19 programmable buttons with 12 side buttons
- Adjustable DPI, polling rate, and removable weights
- Five profiles for different games or tasks
Best For: MMO players and macro-heavy setups
Best Simple Layout
Razer DeathAdder Essential Gaming Mouse
- Five programmable buttons for shortcuts and macros
- Ergonomic right-handed shape
- 6,400 DPI optical sensor with sensitivity adjustment
Best For: Everyday gaming with a familiar button layout
Best Wireless MMO Pick
ASUS ROG Spatha X Gaming Mouse
- 12 programmable buttons with six side buttons
- 2.4GHz wireless and USB-C wired modes
- Up to 67 hours of battery life with RGB off
Best For: Wireless MMO and MOBA gaming
Best All-Around Pick
- 11 programmable buttons with ergonomic thumb-rest design
- 26,000 DPI optical sensor and fast optical switches
- Customizable Hyperscroll wheel and Chroma RGB
Best For: Versatile PC gaming and everyday use
Best Budget MMO Layout
- 18 programmable buttons, including 12 side buttons
- Five profiles, adjustable DPI, and weight tuning
- Wired design with RGB lighting and braided cable
Best For: MMO players needing extensive remappable controls
Best Simple Pick
- Interchangeable 12-, 6-, and 2-button side plates
- Up to 19 plus one programmable buttons
- HyperSpeed wireless and up to 300-hour Bluetooth battery life
Best For: Adaptable wireless MMO and multi-genre gaming
Classic Wired Value – Redragon M602
The Redragon M602 is a practical gaming mouse with side buttons for players who want programmable controls, adjustable sensitivity, and RGB lighting without switching to wireless. Its wired USB connection keeps setup straightforward for PC gaming and everyday work.
Best For: Budget-minded right-handed gamers who want customizable controls and a comfortable wired design.
Pros:
- Offers up to 7200 adjustable DPI for different gaming and work situations.
- Provides programmable buttons, remapping, macro editing, and lighting controls through software.
- Uses an ergonomic right-handed shape with dedicated finger positions.
- Includes seven RGB lighting modes and effects.
Cons:
- Requires a wired USB connection.
- Software customization is intended for supported desktop operating systems.
The M602 is a sensible pick when programmable side controls and customization matter more than wireless convenience or premium sensor specifications.
Long-Lasting Wireless Pick – Razer Basilisk V3 X HyperSpeed
The Razer Basilisk V3 X HyperSpeed is a gaming mouse with side buttons for players who prioritize wireless flexibility and long battery life. It combines low-latency HyperSpeed wireless, Bluetooth, nine customizable controls, and an ergonomic right-handed shape.
Best For: Right-handed gamers who want customizable side controls, multi-device connectivity, and extended battery life.
Pros:
- Supports both low-latency HyperSpeed wireless and Bluetooth connectivity.
- Offers up to 285 hours on HyperSpeed wireless or 535 hours on Bluetooth, according to the supplied specifications.
- Includes nine customizable controls and an 18,000 DPI optical sensor.
- Features Gen-2 mechanical switches rated for up to 60 million clicks and Chroma RGB.
Cons:
- Uses a right-handed design.
- Requires an AA battery for operation.
This model is a strong all-around wireless option for gamers who want accessible side commands without frequent charging, while still retaining Bluetooth for longer-use scenarios.
MMO Command Center – UtechSmart Venus Pro
The UtechSmart Venus Pro is a gaming mouse with side buttons built specifically for MMO-style control schemes. Its 12 thumb buttons, programmable macros, adjustable weighting, and multiple profiles give players substantial room to map skills, shortcuts, and commands.
Best For: MMO players who need many accessible thumb controls and extensive profile customization.
Pros:
- Provides 12 angled side buttons designed for thumb access.
- Supports programmable functions, macros, and five custom profiles.
- Offers adjustable sensitivity from 200 to 16,400 DPI.
- Includes eight removable weights, RGB profile lighting, and a textured ergonomic right-handed shape.
Cons:
- Its large number of buttons may take time to learn.
- Uses a wired USB connection and is specified for Windows systems.
- The design is right-handed only.
Choose the Venus Pro when button density is the priority. It is more specialized than a conventional gaming mouse with side buttons, but its layout is well suited to games with numerous mapped abilities.
Precision Wired Favorite – Logitech G502 HERO
The Logitech G502 HERO is a gaming mouse with side buttons for players who want a familiar wired design with extensive customization. It combines 11 programmable buttons, a 25,600 DPI HERO sensor, adjustable weights, RGB lighting, and a dual-mode scroll wheel.
Best For: Right-handed PC gamers who want precise tracking, numerous programmable controls, and tunable weight balance.
Pros:
- Offers 11 programmable buttons for gameplay commands and shortcuts.
- Uses a HERO sensor with sensitivity up to 25,600 DPI and no smoothing, filtering, or acceleration.
- Includes five removable 3.6-gram weights for personalized balance.
- Features LIGHTSYNC RGB and a dual-mode hyper-fast scroll wheel.
Cons:
- Requires a wired USB connection.
- Uses a right-handed shape.
- Its extensive controls and adjustable weights may feel more involved than a basic mouse.
The G502 HERO is a versatile choice for players who want precise wired tracking and more controls than a standard gaming mouse, especially if weight tuning is important.
Best MMO Value – Redragon M901K 19-Button Gaming Mouse
If you need a gaming mouse with side buttons for MMO abilities, macros, or productivity shortcuts, the Redragon M901K offers an unusually high button count. It combines 19 programmable buttons, adjustable sensitivity, RGB lighting, and removable weights in a wired right-handed design.
Best For: MMO players and users who want extensive button customization at a value-oriented price.
Pros:
- 19 programmable buttons, including 12 side buttons, support remapping and macros.
- Adjustable 100–12,400 DPI sensitivity and polling rates up to 1,000Hz.
- Eight removable 2.4-gram weights allow balance and weight tuning.
- Five memory profiles and multiple RGB lighting modes add configuration flexibility.
Cons:
- The large number of side buttons may take time to learn.
- It is a corded mouse, so it does not offer wireless freedom.
- The design is right-handed only.
The M901K is a strong fit when button access matters more than a minimalist layout. Its extensive customization makes it especially practical for MMO and macro-heavy setups.
Best Simple Layout – Razer DeathAdder Essential Gaming Mouse
The Razer DeathAdder Essential is a straightforward gaming mouse with side buttons for players who want useful shortcuts without a crowded MMO layout. Its five programmable buttons, ergonomic right-handed shape, and 6,400 DPI optical sensor cover everyday gaming and creative work.
Best For: Gamers who prefer a familiar, comfortable mouse with a small number of programmable controls.
Pros:
- Five programmable buttons can be remapped or assigned macro functions.
- The ergonomic right-handed design is suited to extended use.
- Its 6,400 DPI optical sensor supports on-the-fly sensitivity adjustment.
- Mechanical switches are rated for up to 10 million clicks.
Cons:
- It offers far fewer side buttons than dedicated MMO mice.
- The wired design does not provide wireless connectivity.
- Its maximum DPI is lower than the other mice in this selection.
This is the practical choice for buyers who want a gaming mouse with side buttons but do not need a large macro grid. The restrained layout is easier to transition to and keeps the mouse suitable for general gaming.
Best Wireless MMO Pick – ASUS ROG Spatha X Gaming Mouse
The ASUS ROG Spatha X is a premium gaming mouse with side buttons designed around MMO and MOBA play. It provides six strategically positioned side buttons within a 12-button layout, along with dual-mode wireless or USB-C connectivity, a high-resolution sensor, and a magnetic charging dock.
Best For: MMO and MOBA players who want extensive controls with the flexibility of wireless or wired play.
Pros:
- Six side buttons and 12 programmable buttons support detailed game customization.
- Dual-mode connectivity offers low-latency 2.4GHz wireless or USB-C wired use.
- The 19,000 DPI sensor and 1,000Hz polling rate support precise tracking.
- Battery life reaches up to 67 hours with RGB lighting off, and the dock supports convenient charging.
Cons:
- The 168-gram design is relatively heavy.
- Its large right-handed shape may not suit smaller hands or left-handed users.
- The feature-rich design may be more than casual players need.
The Spatha X is the most versatile option here for users who want MMO-style side buttons without giving up wireless operation. Its hot-swappable switches, charging dock, and dual-mode connection make it a feature-rich choice for a dedicated gaming setup.
Best All-Around Pick – Razer Basilisk V3
The Razer Basilisk V3 is a practical choice if you want a gaming mouse with side buttons that balances accessible controls, ergonomic support, and precise tracking. Its 11 programmable buttons, thumb rest, and customizable scroll wheel suit a wide range of PC games.
Best For: PC gamers who want versatile programmable controls in a comfortable right-handed wired design.
Pros:
- 11 programmable buttons provide room for macros and secondary functions.
- Ergonomic shape includes a thumb rest and conveniently positioned controls.
- 26,000 DPI optical sensor and Gen-2 optical switches support precise, responsive input.
- Hyperscroll tilt wheel and 11-zone Chroma RGB add customization and utility.
Cons:
- Wired USB connectivity may be less convenient than a wireless setup.
- Its right-handed shape is not designed for left-handed use.
The Basilisk V3 is a strong middle ground for gamers who need more controls than a basic mouse but do not need an MMO-style button grid. Choose it for its ergonomic layout, fast sensor, and flexible button mapping.
Best Budget MMO Layout – Redragon M908 Impact
The Redragon M908 Impact is built for players who want a gaming mouse with side buttons in a highly customizable MMO layout. It offers 18 programmable buttons, including 12 side buttons, plus onboard profiles, adjustable DPI, and removable weights.
Best For: MMO players and budget-focused gamers who need many remappable controls.
Pros:
- 18 programmable buttons include 12 dedicated side buttons for MMO commands.
- Five memory profiles make it easier to switch control setups.
- Adjustable DPI, 1,000 Hz polling, and a Pixart PAW3327 sensor support responsive play.
- Eight removable weights allow some control over the mouse’s feel.
Cons:
- The wired design limits cable-free flexibility.
- The large number of buttons may take time to learn and organize.
- Programmable functions require Windows; Mac is listed for normal use.
The M908 makes the most sense when button quantity is the priority. Its MMO-focused side grid and profile support offer extensive control, while the adjustable weights and DPI provide useful flexibility at a comparatively straightforward wired setup.
Best Simple Pick – Razer Naga V2 Pro
The Razer Naga V2 Pro is a gaming mouse with side buttons designed for players who want adaptable controls without staying tethered to a cable. Its interchangeable 12-, 6-, and 2-button magnetic side plates let you tailor the layout to MMO, action, or general gaming use.
Best For: Gamers who want premium wireless performance and interchangeable side-button layouts.
Pros:
- Three magnetic side plates provide 2-, 6-, or 12-button configurations.
- Supports up to 19 plus one programmable, backlit buttons.
- HyperSpeed wireless offers low-latency connectivity, while Bluetooth battery life is rated up to 300 hours.
- 30,000 DPI Focus Pro sensor and Gen-3 optical switches emphasize tracking and durability.
Cons:
- Its extensive feature set may be more than needed for simple gaming setups.
- The mouse is right-handed and weighs more than the wired models listed here.
- Wireless charging accessories are sold separately.
The Naga V2 Pro is the most adaptable option in this group. Pick it if you want to change from a dense MMO side grid to a simpler layout while retaining wireless connectivity, a high-resolution sensor, and long rated battery life.
How We Picked the Best Gaming Mouse with Side Buttons
We focused on practical differences that affect everyday gaming rather than judging by button count alone. The lineup includes simple two-button designs for FPS players, versatile ergonomic models for mixed genres, and MMO-focused mice with dense side-button grids. We also considered wired versus wireless connectivity, programmable controls, DPI ranges, shape, weight, RGB lighting, software support, and whether each mouse is designed primarily for right-handed use.
Because specifications vary widely, treat maximum DPI as a flexibility feature rather than a performance guarantee. Sensor consistency, comfortable tracking, reliable switches, and a shape that suits your grip matter more than a headline number.
Quick Comparison
- Best for MMO command-heavy play: Choose a model with a 12-button side grid, such as the Redragon MMO options, ASUS ROG Spatha X, or Razer Naga V2 Pro.
- Best for mixed genres: The Razer Basilisk models and Logitech G502 Hero balance accessible side controls with familiar ergonomic shapes.
- Best for a simpler layout: The Razer DeathAdder Essential and Redragon M602 offer useful side buttons without an oversized MMO keypad.
- Best for wireless flexibility: The Razer Basilisk V3 X HyperSpeed, ASUS ROG Spatha X, and Razer Naga V2 Pro provide wireless play while retaining programmable controls.
- Best for extensive customization: Look to the Naga V2 Pro, Spatha X, or a Redragon MMO model, depending on whether you prioritize modularity, premium wireless features, or value.
Key Buying Factors for a Gaming Mouse with Side Buttons
Button Layout and Quantity
Two side buttons are usually enough for shooters and general desktop use. MMO and productivity users may benefit from six to twelve thumb buttons, but crowded layouts take time to learn and can cause accidental presses. Check whether the buttons are distinct enough to identify by touch.
Shape, Grip, and Weight
Large ergonomic mice can support palm grips, while narrower designs may suit claw or fingertip users. Extra buttons, wireless batteries, and adjustable weights add mass. A heavier mouse can feel stable, but a lighter one is often easier to move quickly in competitive games.
Connection and Battery Needs
Wired mice avoid charging and generally offer straightforward setup. Wireless models are more convenient for a clean desk, but check battery claims, charging options, wireless modes, and whether performance changes when using the cable.
Software and Remapping
Confirm that the companion software supports profiles, macros, DPI stages, lighting, and onboard memory if those features matter to you. Software quality can determine how easy it is to configure a Gaming Mouse with Side Buttons across multiple games or computers.
Who Should Buy Which Gaming Mouse with Side Buttons?
FPS and general gamers should favor a comfortable, less cluttered mouse such as the DeathAdder Essential, M602, Basilisk V3, or G502 Hero. MMO and MOBA players should consider a 12-button design when rapid access to abilities outweighs a simpler shape. Wireless-focused buyers should compare the Basilisk V3 X HyperSpeed, Spatha X, and Naga V2 Pro based on battery priorities, button requirements, and budget. Value shoppers will generally find the Redragon models compelling, while buyers who want a polished ecosystem and refined software may prefer a Razer, Logitech, or ASUS option.